Have your cake and eat it too.

A 2024 study found fasting itself runs on spermidine.

Fast, and your spermidine goes up. When scientists blocked it, fasting's cleanup slowed, and its longer-life effect disappeared.

It was published in Nature Cell Biology.

That cleanup is autophagy, the process by which every cell in your body takes out the trash. The Nobel Prize was awarded in 2016 for discovering how autophagy works.

Spermidine triggers autophagy without skipping a meal. It activates the exact same renewal pathways as a prolonged fast.

Spermidine is also linked to nearly 6 years of longer life. It's behind fuller hair, stronger nails and firmer skin, and it supports your brain, heart and immune system.

In a placebo-controlled study lasting 90 days, spermidine pushed significantly more follicles back into active growth. Hair is usually where people see it first.

SPMD-99 is spermidine at 99+% purity. Every serving delivers a full 20mg, which meets or exceeds the dosage in every major study linking spermidine to a longer life.

Double the spermidine of 4 out of the 5 top competitors tested. Measured by an independent 3rd-party lab.

See every brand's lab report.

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The Opus Longevity Team