Spermidine ranked #1 of 146 compounds.

Here's what spermidine does in every cell.

Spermidine triggers autophagy, the process every cell uses to take out its trash. It's the deep cellular cleanup that fasting is famous for, without skipping a meal.

The Nobel Prize was awarded in 2016 for discovering how autophagy works.

In the 20-year study in Italy, scientists tracked what 829 people ate, and how long they lived.

Of 146 compounds, spermidine had the strongest link to a longer life. Nearly six more years.

It was published in the American Journal of Clinical Nutrition.

Spermidine is also behind fuller hair, stronger nails and firmer skin, and it supports your brain, heart and immune system.

In a placebo-controlled study lasting 90 days, spermidine pushed significantly more follicles back into active growth. Hair is usually where people see it first.

SPMD-99 is spermidine at 99+% purity. Every serving delivers a full 20mg, which meets or exceeds the dosage in every major study linking spermidine to a longer life.

Double the spermidine of 4 out of the 5 top competitors tested. Measured by an independent 3rd-party lab.

See every brand's lab report.

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The Opus Longevity Team